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Anemia, Aplastic

Muthalagu Ramanathan, MD and Jan Cerny, MD, PhD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Pancytopenia due to hypocellular bone marrow without the presence of infiltrates or fibrosis; classified as acquired (much more common) and congenital

  • Acquired aplastic anemia: insidi...

DIAGNOSIS

HISTORY

  • Solvent and radiation history; family, environmental, travel, and infectious disease history

  • Patients are often asymptomatic but may have frequent infections, fatigue, shortness of bre...

TREATMENT

Early treatment increases the chance of success. Two major options: immunosuppressive therapy (3) and hematopoietic stem cell transplantation. Treatment decisions are based on age of the pat...

ONGOING CARE

DIET

If neutropenic, avoid foods that can expose patient to bacteria, such as uncooked foods. https://www.lls.org/managing-your-cancer/diet-guidelines-for-immunosuppressed-patients 

PATIENT EDUCATION

REFERENCES

1
1 Brodsky RA, Jones RJ. Aplastic anaemia. Lancet.  2005;365(9471):1647–1656. {L-End} {L-End} [View Abstract on OvidMedline]
2
2 Bueno C, Roldan M, Anguita E, et al. Bone marrow mesen...

SEE ALSO

  • Lupus Erythematosus, Systemic (SLE)

  • Algorithm: Anemia

  • Myelodysplastic Syndromes (MDS)

CODES

ICD10

  • D61.9 Aplastic anemia, unspecified

  • D61.89 Oth aplastic anemias and other bone marrow failure syndromes

  • D61.01 Constitutional (pure) red blood cell aplasia

  • D61.1 Drug-induced aplastic anemia

  • D61...

CLINICAL PEARLS

  • Acquired aplastic anemia has an insidious onset and is caused by an exogenous insult triggering an autoimmune reaction. This form is usually responsive to immunosuppressive therapy.

  • Imm...

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