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Angioedema

Michelle T. Martin, PharmD, FCCP, BCPS, BCACP and Jamie L. Berkes, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Angioedema (AE) is acute, localized swelling of skin, mucosa, and submucosa caused by extravasation of fluid into the affected tissues. It often resolves in hours to days but can be ...

DIAGNOSIS

HISTORY

  • Identify potential triggers, including medication history, recent exposure to allergens, physical elements, or trauma.

  • In comparison with urticaria, AE typically is nonpruritic, but it...

TREATMENT

GENERAL MEASURES

Intubation if airway is threatened 

MEDICATION

First Line

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

  • Diagnostic workup if symptoms are severe, persistent, or recurrent

  • Protect airway if mouth, tongue, or throat is involved.

DIET

Avoid known dietary...

REFERENCES

1
1 Temiño VM, Peebles RSJr. The spectrum and treatment of angioedema. Am J Med.  2008;121(4):282–286. {L-End} {L-End} [View Abstract on OvidMedline]
2
2 LoVerde D, Files DC, Krishnasw...

ADDITIONAL READING

  • Bernstein JA, Cremonesi P, Hoffmann TK, et al. Angioedema in the emergency department: a practical guide to differential diagnosis and management. Int J Emerg Med.  2017;10(1):...

SEE ALSO

Anaphylaxis; Urticaria 

CODES

ICD10

  • T78.3XXA Angioneurotic edema, initial encounter

  • D84.1 Defects in the complement system

ICD9

  • 995.1 Angioneurotic edema, not elsewhere classified

  • 277.6 Other deficiencies of circulating enzymes

SNOMED

CLINICAL PEARLS

  • AE is an acute, localized swelling of skin, mucosa, and submucosa caused by extravasation of fluid into the affected tissues. It often resolves in hours to days, but it can be life-thr...

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