Antiphospholipid Antibody Syndrome

Edwin Seelye, DO and Troy Sterk, DO Reviewed 06/2018
 


BASICS

DESCRIPTION

Antiphospholipid antibody syndrome (APS) is an autoantibody-mediated thrombophilic disorder characterized by recurrent arterial or venous thrombosis and/or recurrent fetal loss in th...

DIAGNOSIS

Sapporo criteria, revised 2006: 
  • At least one of the following clinical criteria:

    • Vascular thrombosis

      • ≥1 clinical episodes of arterial, venous, or small vessel thrombosis, occurring within ...

TREATMENT

MEDICATION

First Line

  • Primary thromboprophylaxis: Low-dose aspirin is indicated in asymptomatic carriers of APAs with SLE and in pregnancy. It may be considered in other asymptomatic carriers....

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

  • Standard guidelines for monitoring to maintain INR at goal with warfarin therapy

  • Close monitoring is required during pregnancy.

DIET

Heart-healthy ...

REFERENCES

1 Bertolaccini ML, Amengual O, Andreoli L, et al. 14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and tren...

ADDITIONAL READING

  • Bramham K, Thomas M, Nelson-Piercy C, et al. First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss. Blood.  2011;117(25):6948–695...

CODES

ICD10

  • D68.61 Antiphospholipid syndrome

  • D68.69 Other thrombophilia

  • D68.62 Lupus anticoagulant syndrome

ICD9

  • 289.81 Primary hypercoagulable state

  • 289.82 Secondary hypercoagulable state

SNOMED

  • 26843008 ant...

CLINICAL PEARLS

  • APS can be either primary, secondary, or present as a severe microvascular disease known as CAPS.

  • Both clinical and laboratory criteria are required for diagnosis. The latter must be co...

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