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Aspergillosis

Christine Bryson, DO Reviewed 06/2018
 


BASICS

DESCRIPTION

  • A spectrum of diseases caused by species of the ubiquitous mold, Aspergillus

    • Saprophytic: chronic pulmonary aspergillosis (CPA), aspergilloma, chronic cavitary, chronic fibrosing, chr...

DIAGNOSIS

HISTORY

  • Symptoms depend on the site of infection and may include fever, dyspnea, cough, sinus congestion/pain.

  • Brownish/black sputum in half of patients with ABPA

  • Patients may develop pleuritic...

TREATMENT

GENERAL MEASURES

  • ABPA may improve with allergen avoidance and optimal asthma control.

  • Depending on the clinical picture, treatment of aspergilloma may include observation, oral antifungal ther...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • ABPA: serum IgE levels (goal: to decrease levels by 25–50%), CXR, pulmonary function test, every 6 to 8 weeks to objectively assess for remissio...

REFERENCES

1
Agarwal R, Chakrabarti A, Shah A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy.  2...

CODES

ICD10

  • B44.9 Aspergillosis, unspecified

  • B44.1 Other pulmonary aspergillosis

  • B44.81 Allergic bronchopulmonary aspergillosis

  • B44.89 Other forms of aspergillosis

  • B44.0 Invasive pulmonary aspergillosis

  • B44...

CLINICAL PEARLS

  • Although Aspergillus spp. are ubiquitous, most immunocompetent people do not acquire disease.

  • Diagnosis of aspergillosis can be challenging and is based on history, physical exam, and a...

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