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Bartter Syndrome

Reviewed 06/2018
 


BASICS

  • Bartter syndrome and Bartter-like syndrome are a group of rare, autosomal recessive, salt-wasting nephropathies characterized by polyuria, hypokalemia, metabolic alkalosis, and normotension wit...

DIAGNOSIS

HISTORY

  • Polyuria and polydipsia are always present, and there is a history of episodes of dehydration.

  • In types I (pure furosemide), II, IV (furosemide-thiazide), and V, the presentation is us...

TREATMENT

  • The main goal in the neonatal period is to keep up with severe fluid and NA losses as well as correcting hypokalemia (7).

  • In Gitelman, correction of hypomagnesemia is also important.

MEDICATION

ONGOING CARE

DIET

High in salt, K, and water 

PROGNOSIS

Good in general. With adequate management, patients can grow normally. 

COMPLICATIONS

Nephrocalcinosis, gastric ulcers, chronic kidney disease 

REFERENCES

1
Chadha V, Alon US. Hereditary renal tubular disorders. Semin Nephrol.  2009;29(4):399–411. {L-End} [View Abstract on OvidMedline]
2
Seyberth HW. An improved terminology and classificat...

ADDITIONAL READING

  • Brochard K, Boyer O, Blanchard A, et al. Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome. Nephrol Dial Transplant.  2009;24(5):1455–1464.

  • N...

CODES

ICD10

E26.81 Bartter's syndrome 

ICD9

255.13 Bartter's syndrome 

SNOMED

  • 236465009 Bartter's syndrome with hypercalciuria and nephrocalcinosis (disorder)

  • 700107006 Bartter syndrome antenatal type 1 (di...

CLINICAL PEARLS

Bartter and Bartter-like syndromes are rare autosomal recessive, hypokalemic, salt-losing nephropathies that mimic diuretic effects. 

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