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Brucellosis

Jeffrey H. Walden, MD, FAAFP Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Systemic granulomatous bacterial infection caused by Brucella sp. resulting in febrile illness; typically from ingestion of raw milk, unpasteurized milk, infected meat, or contact wi...

DIAGNOSIS

HISTORY

  • Nonspecific systemic febrile illnesses; “great mimic”

  • Constellation of fever (often high, undulant—increased in afternoon and evening), weakness, headache, sweating, chills, generalize...

TREATMENT

GENERAL MEASURES

  • Report cases to local public health department.

  • Supportive care

  • In milk-related or occupational outbreak, case surveillance and public health reporting

  • Bed rest during febrile p...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Check serology at 6 months and 1 year for chronic disease (difficult to evaluate if continuing exposure).

  • Investigate any suspicion of recurrence...

REFERENCES

1
Solera J, Solís García del Pozo J. Treatment of pulmonary brucellosis: a systematic review. Expert Rev Anti Infect Ther.  2017;15(1):33–42. {L-End} [View Abstract on OvidMedline]
2
San...

ADDITIONAL READING

  • Dean AS, Crump L, Greter H, et al. Clinical manifestations of human brucellosis: a systematic review and meta-analysis. PLoS Negl Trop Dis.  2012;6(12):e1929.

  • Skalsky K, Yahav D...

CODES

ICD10

  • A23.9 Brucellosis, unspecified

  • A23.8 Other brucellosis

  • A23.0 Brucellosis due to Brucella melitensis

  • A23.2 Brucellosis due to Brucella suis

  • A23.1 Brucellosis due to Brucella abortus

  • A23.3 Brucell...

CLINICAL PEARLS

  • Brucellosis is challenging to diagnose.

  • Brucellosis is characterized by intermittent or irregular fevers, with symptoms ranging from subclinical disease to infection of almost any organ...

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