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Chronic Fatigue Syndrome (CFS)

Yow-Jeng Franny Pan, MD and Naureen Rafiq, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • A complex physical illness characterized by a new or definite onset of debilitating fatigue that persists for >6 months and significantly reduces a person’s ability to perform usu...

DIAGNOSIS

HISTORY

A thorough medical history and psychosocial history is required for accurate diagnosis. Box 1 shows updated diagnostic criteria proposed by the Institute of Medicine. 
ALERT

Box 1. 2015...

TREATMENT

  • No treatment yet proven effective by large randomized trials; recommendations based on expert opinion and standard symptom management (1,2)

  • Focus on changes in lifestyle and insight, with a g...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

Although no consensus exists, periodic reevaluation is appropriate for support, relief of symptoms, and assessment for other possible causes of ...

REFERENCES

1
1 Unger ER, Lin JS, Brimmer DJ, et al. CDC grand rounds: chronic fatigue syndrome—advancing research and clinical education. MMWR Morb Mortal Wkly Rep.  2016;65(5051):1434–1438. {L-En...

ADDITIONAL READING

SEE ALSO

Algorithm: Fatigue 

CODES

ICD10

R53.82 Chronic fatigue, unspecified 

ICD9

780.71 Chronic fatigue syndrome 

SNOMED

52702003 Chronic fatigue syndrome (disorder) 

CLINICAL PEARLS

  • No pharmacologic agents (e.g., antidepressants, immune modulators) have been shown to be consistently effective in treating CFS.

  • ~70% of patients show improvement with CBT; 55% with GET...

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