Coccidioidomycosis

Maria M. Plummer, MD and Charles Pavia, PhD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • A pulmonary fungal infection caused by the dimorphic fungus, Coccidioides immitis, which is endemic to the southwestern deserts of the United States:

    • Inhalation of air-borne fungal sp...

DIAGNOSIS

HISTORY

  • Take a thorough travel history, particularly when investigating pulmonary conditions not responding to normal measures.

  • Most humans infected with coccidioidomycosis are asymptomatic or...

TREATMENT

GENERAL MEASURES

  • Cool mist humidifier for dry cough or sore throat, antitussives

  • Supportive therapy

  • Most cases resolve without antifungal treatment.

MEDICATION

First Line

  • In mild cases, treatment ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • If serology is negative but index of suspicion is high, repeat serology every 2 weeks.

  • With positive serology, follow titers every 2 weeks until ...

REFERENCES

Thompson GRIII. Pulmonary coccidioidomycosis. Semin Respir Crit Care Med.  2011;32(6):754–763.  [View Abstract]
Ruddy BE, Mayer AP, Ko MG, et al. Coccidioidomyocosis in African Americ...

ADDITIONAL READING

  • Miller MB, Hendren R, Gilligan P. Posttransplantation disseminated coccidiomycosis acquired from donor lungs. J Clin Microbiol.  2004;42(5):2347–2349.

  • Ramos-e-Silva M, Lima CM, ...

CODES

ICD10

  • B38.9 Coccidioidomycosis, unspecified

  • B38.2 Pulmonary coccidioidomycosis, unspecified

  • B38.0 Acute pulmonary coccidioidomycosis

  • B38.1 Chronic pulmonary coccidioidomycosis

  • B38.89 Other forms of c...

CLINICAL PEARLS

  • Consider coccidioidomycosis in patients with travel to endemic areas and persistent pulmonary symptoms that do not respond to routine treatment.

  • Minimal exposure in an endemic area can ...

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