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Cryoglobulinemia

Saadia Mohsin, MD and Kashif S. Anwar, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Cryoglobulins (CGs) consist of immunoglobulins (Igs) and complement precipitating in serum and plasma.

  • CGs precipitate at cold temperatures 98.6°F (<37°C) and dissolve on rewarming...

DIAGNOSIS

  • Triad: palpable purpura, arthralgia, myalgia

  • Type I

    • Commonly asymptomatic

    • More frequent association with signs of peripheral vessel occlusion (e.g., Raynaud phenomenon, acrocyanosis, livedo ret...

TREATMENT

  • Goals:

    • Symptomatic management of vasculitis and/or hyperviscosity and limit damage caused by circulating immune complexes

    • Limit or suppress B-lymphocyte proliferation.

    • Eradicate HCV (if applica...

ONGOING CARE

DIET

Mixed CG: Low-antigen content (LAC) diet is suggested for symptomatic improvement (no meat except turkey; no eggs, dairy products, or food additives; no preservatives; no beverages ex...

REFERENCES

1
Takada S, Shimizu T, Hadano Y, et al. Cryoglobulinemia (review). Mol Med Rep.  2012;6(1):3–8. {L-End} [View Abstract on OvidMedline]
2
Porres-Aguilar M, Rodriguez-Castro CE, Osvaldo P,...

ADDITIONAL READING

  • Alpers CE, Smith KD. Cryoglobulinemia and renal disease. Curr Opin Nephrol Hypertens.  2008;17(3):243–249.

  • Anis S, Abbas K, Mubarak M, et al. Vasculitis with renal involvement i...

CODES

ICD10

D89.1 Cryoglobulinemia 

ICD9

273.2 Other paraproteinemias 

SNOMED

  • 30911005 cryoglobulinemia (disorder)

  • 38675009 Monoclonal cryoimmunoglobulinemia (disorder)

  • 44371002 Mixed polyclonal cryoimmunogl...

CLINICAL PEARLS

  • CGs are circulating Igs that precipitate at cold temperatures (below 37°C) and dissolve on rewarming.

  • Type I: associated with lymphoproliferative disorders (e.g., multiple myeloma, Wald...

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