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Dengue Fever

Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Dengue fever or “breakbone fever” is caused by an arbovirus—dengue virus (DENV)—a Flavivirus, from the Flaviviridae family.

  • Single-stranded positive RNA virus with four antigenically ...

DIAGNOSIS

HISTORY

  • Symptoms begin after a 3- to 7-day incubation period.

  • Dengue fever presents with

    • High fever (>38.5°C—may be biphasic)

    • Headache

    • Cough, sore throat, and nasal congestion

    • Relative bradycar...

TREATMENT

GENERAL MEASURES

  • No prophylaxis or treatment is currently available.

  • Supportive care with bed rest, hydration, pain, and fever control are mainstays of treatment.

MEDICATION

First Line

  • Volume res...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

All patients should be referred to an infectious disease specialist. Dengue is reportable to the CDC: Dengue Branch 1324 Calle Cañada San Juan, Puerto Rico 00920-...

REFERENCES

1
Guzman MG, Halstead SB, Artsob H, et al. Dengue: a continuing global threat. Nat Rev Microbiol.  2010;8(Suppl 12):S7–S16. {L-End} [View Abstract on OvidMedline]
2
Simmons CP, Farrar JJ...

ADDITIONAL READING

  • Centers for Disease Control and Prevention. CDC Web site. http://www.cdc.gov/dengue/. Accessed March 14, 2018.

  • Guzman MG, Harris E. Dengue. Lancet.  2015;385(9966):453–465.

CODES

ICD10

  • A90 Dengue fever [classical dengue]

  • A91 Dengue hemorrhagic fever

ICD9

  • 061 Dengue

  • 065.4 Mosquito-borne hemorrhagic fever

SNOMED

  • 38362002 Dengue (disorder)

  • 20927009 Dengue hemorrhagic fever (disorde...

CLINICAL PEARLS

  • Mosquito control is the most effective approach to dengue prevention.

  • Treatment requires active intravascular volume repletion to prevent or reverse hypovolemic shock

  • Aspirin or NSAIDs s...

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