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Diabetes Insipidus

Sasmit Roy, MD and Jahan Montague, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • A condition in which there is reduced ability to concentrate the urine due to impaired reabsorption of water in the renal collecting tubules

  • It is characterized by polyuria and, in se...

DIAGNOSIS

  • Can be challenging, given the variety of causes and variable symptomatology

  • DI not resulting from a recognizable, acute event (e.g., head trauma) tends to be indolent and, if water needs are ...

TREATMENT

GENERAL MEASURES

  • Control fluid balance; prevent dehydration.

  • Check weight daily.

  • Careful follow-up and management of electrolytes

  • NDI: Correct hypercalcemia and hypokalemia, and discontinue caus...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Regular follow-up at 2- to 3-week intervals initially and 3 to 4 months later

  • Adjust treatment on the basis of urine and electrolyte concentratio...

REFERENCES

Aleksandrov N, Audibert F, Bedard MJ, et al. Gestational diabetes insipidus: a review of an underdiagnosed condition. J Obstet Gynaecol Can.  2010;32(3):225–231.  [View Abstract]
Krah...

CODES

ICD10

  • E23.2 Diabetes insipidus

  • N25.1 Nephrogenic diabetes insipidus

ICD9

  • 253.5 Diabetes insipidus

  • 588.1 Nephrogenic diabetes insipidus

SNOMED

  • 15771004 Diabetes insipidus (disorder)

  • 111395007 Nephrogenic...

CLINICAL PEARLS

  • To distinguish primary polydipsia from DI in a patient with polyuria, a patient with primary polydipsia will have a normal response to a water restriction test and normal levels of pla...

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