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Fox-Fordyce Disease

Reviewed 06/2018
 


BASICS

DESCRIPTION

A rare chronic pruritic skin condition involving apocrine glands. Named for the physicians who first described it (1); also known as apocrine duct occlusion or apocrine miliaria; cau...

DIAGNOSIS

HISTORY

  • The development of pruritic papules at the time of puberty with gradual worsening

  • Patient will complain of extreme pruritus.

  • Heat, humidity, sweating, and stress exacerbate symptoms.

PHYSICAL EXAM

TREATMENT

GENERAL MEASURES

  • Nonsurgical treatment is difficult because no single treatment has been shown to be very effective but involves the avoidance of excessive sweating or heat. Consider dermatol...

ONGOING CARE

PATIENT EDUCATION

Avoid activities that may result in increased sweating as this can exacerbate the disease. 

PROGNOSIS

Lesions may last months to years or may subsequently resolve with trea...

REFERENCES

1
Fox GH, Fordyce JA. Two cases of a rare popular disease affecting the axillary region. J Cutan Genitourinary Dis.  1902;20:1–5.
2
Kamada A, Saga K, Jimbow K. Apoeccrine sweat duct obstr...

ADDITIONAL READING

  • Bormate ABJr, Leboit PE, McCalmont TH. Perifollicular xanthomatosis as the hallmark of axillary Fox-Fordyce disease: an evaluation of histopathologic features of 7 cases. Arch Derma...

CODES

ICD10

L75.2 Apocrine miliaria 

ICD9

705.82 Fox-Fordyce disease 

SNOMED

  • 65038009 Fox-Fordyce disease

  • 403372003 Fox-Fordyce disease of axillae

  • 403373008 Fox-Fordyce disease of vulva (disorder)

CLINICAL PEARLS

  • Fox-Fordyce presents as chronic pruritic papules in areas where sweat glands are concentrated.

  • Pruritus may be extreme and out of proportion to the erythema.

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