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Glomerulonephritis, Acute

Jonathan T. Lin, MD and Michael J. Ross, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Acute glomerulonephritis (GN) is an inflammatory process involving the glomerulus of the kidney, resulting in a clinical syndrome consisting of hematuria, proteinuria, and renal insu...

DIAGNOSIS

HISTORY

  • Patients may report cola- or tea-colored urine and decreased urine volume.

  • Edema occurs in many patients, typically in face and lower extremities.

  • Shortness of breath may occur with sig...

TREATMENT

Supportive in postinfectious GN 

MEDICATION

First Line

  • Hypertension

    • Diuretics are useful for management of salt retention and edema.

    • Calcium channel blockers

    • Avoid angiotensin-converting enzyme ...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

  • Depends on type of GN

  • Regular BP checks and urinalysis to detect recurrence, assessment of renal function to detect acute or follow chronic renal...

REFERENCES

1
Chadban SJ, Atkins RC. Glomerulonephritis. Lancet.  2005;365(9473):1797–1806. [View Abstract on OvidMedline]
2
Beck L, Bomback AS, Choi MJ, et al. KDOQI US commentary on the 2012 KDIGO...

ADDITIONAL READING

  • Bomback AS, Appel GB. Updates on the treatment of lupus nephritis. J Am Soc Nephrol.  2010;21(12):2028–2035. [View Abstract on OvidMedline]

  • Kidney Disease: Improving Global Out...

SEE ALSO

  • Glomerulonephritis, Postinfectious; Henoch-Schönlein Purpura; Hyperkalemia; Hypertensive Emergencies; IgA Nephropathy; Lupus Nephritis; Nephrotic Syndrome; Vasculitis

  • Algorithm: Acute Kidney I...

CODES

ICD10

  • N00.9 Acute nephritic syndrome with unsp morphologic changes

  • N00.2 Acute nephritic syndrome w diffuse membranous glomrlneph

  • N00.8 Acute nephritic syndrome with other morphologic changes

  • N00.3 ...

CLINICAL PEARLS

  • Dysmorphic RBCs and RBC casts are a key component of the urinalysis in GN.

  • Postinfectious GN in children is typically a self-limited disease.

  • Searching for other organ involvement is use...

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