Multiple Sclerosis

Jack R. Stacey, MD and Andrew J. McDermott, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • An autoimmune disease directed against components of the myelin sheath causing demyelination often leading to progressive axonal loss and eventual CNS atrophy affecting primarily whi...

DIAGNOSIS

A person with MS can present with a number of neurologic signs and symptoms depending on the locations of the lesion. The essential means of diagnoses is to demonstrate evidence of CNS lesio...

TREATMENT

GENERAL MEASURES

  • Holistic multidisciplinary team approach is paramount.

  • Three main categories currently exist for MS treatment: treatment for acute relapses, treatment for reducing MS-related ...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

Assessing the severity of neurologic impairment from MS can be done using the Kurtzke Expanded Disability Status Scale (EDSS): The EDSS quantifi...

REFERENCES

1 Raffel J, Wakerley B, Nicholas R. Multiple sclerosis. Medicine.  2016;44(9):537–541.
2 Amato MP, Bertolotto A, Brunelli R, et al. Management of pregnancy-related issues in multiple ...

ADDITIONAL READING

Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Immunology.  2015;15(9):545–558.  [View Abstract] 

CODES

ICD10

G35 Multiple sclerosis 

ICD9

340 Multiple sclerosis 

SNOMED

  • 24700007 Multiple sclerosis (disorder)

  • 428700003 Primary progressive multiple sclerosis

  • 425500002 secondary progressive multiple sclero...

CLINICAL PEARLS

  • MS is an immune-mediated inflammatory disease causing demyelination, neuronal loss, and scarring within the CNS.

  • Diagnosis is made with the McDonald criteria and must demonstrate damage...

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