Acute Kidney Injury, Pediatric

Reviewed 06/2017



  • Acute kidney injury (AKI) is defined as an abrupt (within 48 hours) reduction in kidney function with an absolute increase in serum creatinine of more than or equal to 0.3 mg/dL, or ...



  • Previous infection, neurogenic bladder, single kidney

  • Exposure to nonsteroidal anti-inflammatory agents, β-lactam antibiotics, acyclovir, aminoglycosides, amphotericin B, cisplatin

  • Gros...



  • Clearance of many medications is impaired in AKI. Careful monitoring of drug dosing and levels can minimize toxicity.

  • Low-dose (renal dose) dopamine is ineffective in improving kidn...

Ongoing Care

Follow-up Recommendations

  • The likelihood of recovery from AKI depends on the underlying cause.

  • AKI may result in full recovery or incomplete recovery leading to chronic kidney disease. In s...

Additional Reading

  • Fortenberry  JD, Paden  ML, Goldstein  SL. Acute kidney injury in children: an update on diagnosis and treatment. Pediatr Clin North Am.  2013;60(3):669–688. [View Abstract]

  • KDI...



  • 584.9 Acute kidney failure, unspecified

  • 584.5 Acute kidney failure with lesion of tubular necrosis

  • 580.9 Acute glomerulonephritis with unspecified pathological lesion in kidney

  • 580.89 Acute gl...


  • Q: What is the expected recovery time in patients with AKI who present with anuria?

  • A: Recovery time depends on the etiology of the AKI. Children with HUS may recover in days to weeks. In severe HU...

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