Acute Lymphoblastic Leukemia, Pediatric

Reviewed 06/2017



  • Acute lymphoblastic leukemia (ALL) is a hematopoietic malignancy that results from malignant proliferation of immature WBC (B cells and T cells).

  • Risk group classification:

    • Infant ALL:...


  • Clinical features due to direct invasion of the bone marrow:

    • Pancytopenia: anemia, thrombocytopenia, leukopenia, or neutropenia

    • Anemia: irritability, fatigue, anorexia, headache, pallor

    • Thrombo...


  • Patient suspected with ALL must be referred to a pediatric oncologist as soon as possible for further evaluation and management.

  • Initial emergent stabilization may be required in case of

    • Hyper...

Ongoing Care

Follow-up Recommendations

  • Early intensification has led to an increase in relapse-free survival.

Patient Monitoring

After completion of therapy: 
  • CBC, complete metabolic panel with LDH, liver...

Additional Reading

  • Borowitz  MJ, Devidas  M, Hunger  SP, et al. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic fac...



  • 204 Acute lymphoid leukemia without mention of having achieved remission

  • 204.01 Acute lymphoid leukemia, in remission

  • 204.02 Acute lymphoid leukemia, in relapse


  • C91.00 Acute lymphoblastic...


  • Q: Can a child on treatment for ALL go to school or leave the house?

  • A: Yes. Most centers encourage the child to live a normal life, including school, activities, and travel.

  • Q: Will hair fall out a...

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