Aplastic Anemia, Pediatric

Craig M. Forester and James N. Huang Reviewed 06/2017
 


Basics

Description

Aplastic anemia represents a heterogenous group of disorders characterized by peripheral pancytopenia and bone marrow hypocellularity. 

Epidemiology

Incidence

  • Estimated incidence of 2:1...

Diagnosis

History

  • Detailed history including birth history, growth trajectory, antecedent illnesses, infections, environmental exposures

  • Comprehensive review of systems with emphasis on neurologic (incl...

Treatment

Treatment for aplastic anemia that does not meet the severe or very severe criteria is individualized and controversial as some patients do spontaneously improve. However, patients with seve...

Ongoing Care

Follow-up Recommendations

Regardless of whether IST or BMT is chosen for treatment modality, follow-up should be lifelong given risk of recurrence of aplastic anemia or transformation to M...

Additional Reading

  • Bacigalupo  A, Passweg  J. Diagnosis and treatment of acquired aplastic anemia. Hematol Oncol Clin North Am.  2009;23(2):159–170. [View Abstract]

  • Marsh  JC, Ball  SE, Cavenagh  ...

Codes

ICD09

  • 284.9 Aplastic anemia, unspecified

  • 284.89 Other specified aplastic anemias

  • 284.09 Other constitutional aplastic anemia

ICD10

  • D61.9 Aplastic anemia, unspecified

  • D61.89 Oth aplastic anemias and ot...

FAQ

  • Q: When starting IST, should I choose horse ATG or rabbit ATG as part of the ATG/cyclosporine/prednisone regimen?

  • A: A head to head comparison of horse ATG (hATG) versus rabbit ATG (rATG) in immuno...

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