Rash: usually first manifestation; pruritus or burning sensation can precede rash.
Diarrhea, abdominal pain, and intestinal bleeding: unusual to precede skin disease
Prophylaxis for P. jiroveci pneumonia and pneumococcal infection
Antifungal coverage if on multiple immunosuppressive agents
Monitor closely for vira...
Corticosteroids: osteoporosis, diabetes
Calcineurin inhibitors: hypertension, renal dysfunction, hypomagnesemia
Sirolimus: hyperlipidemia, leukope...
Carpenter PA, Macmillan ML. Management of acute graft-versus-host disease in children. Pediatr Clin North Am. 2010;57(1):273–295. [View Abstract on OvidInsights]
Dhir S, Slatte...
279.50 Graft-versus-host disease, unspecified
279.51 Acute graft-versus-host disease
279.52 Chronic graft-versus-host disease
279.53 Acute on chronic graft-versus-host disease
Q: Do all patients with acute GVHD get chronic GVHD?
A: No. ~30% of patients <10 years of age who receive HLA-identical sibling HSCT will get acute GVHD, whereas only 13% will develop chronic GV...
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