Increased release of norepinephrine, dopamine, and serotonin
Decreased catecholamine reuptake
Direct effect on α- and β-adrenergic receptors
Seizures and status epilepticus
Patient may be uncooperative or violent.
Secure IV access.
Protect from self-induced trauma.
Establish IV 0.9% NS access.
Persistent altered mental status
Asymptomatic after 6 hr observation
Admit patients with severe or persistent symptoms.
Monitor core temperature:
Hyperthermia >40°C may be life threatening.
Treat with aggressive sedation and active cooling.
Callaway CW, Clark RF. Hyperthermia in psychostimulant overdose. Ann Emerg Med. 1994;24:68–75.
Carvalho M, Carmo H, Costa VM, et al. Toxicity of amphetamines: an update. A...
969.72 Poisoning by amphetamines
969.73 Poisoning by methylphenidate
969.79 Poisoning by other psychostimulants
969.70 Poisoning by psychostimulant, unspecified
T43.601A Poisoning by unsp p...
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