Progressive, incurable disease of adults
Neurodegenerative disease of the motor system at all levels
Some patients have associated dementia
Asymmetric limb weakness is the most common presentation of ALS (80%)
May begin in either the arms (cervical onset) or the legs (lumbar onset):
Later all limbs are affected
There is no specific therapy for ALS
The drug riluzole, a glutamate release inhibitor, has been shown to extend survival in ALS patients for an average of a few months
Treatment issues in the ...
Need for respiratory support
Unable to be cared for at home owing to progression of illness
Complications (e.g., infection) or other diagnosis that requ...
ALS is a progressive neurodegenerative disease affecting all components of the motor system
Many patients with ALS have advanced directives—inquire prior to any aggressive intervent...
EFNS Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis, Andersen PM, Abrahams S, et al. EFNS guidelines on the clinical management of amyotrophic lateral scl...
86044005 Amyotrophic lateral sclerosis (disorder)
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