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Contrast Allergy and Reactions

Matthew S. Peckham, MD and Byron Chen, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • A contrast allergy or reaction is the immunologic or physiologic response to IV iodinated contrast media (ICM) administered during a CT scan.

  • Reaction timing can be acute or delayed (...

DIAGNOSIS

HISTORY

  • Prior reaction to ICM

  • Other risk factors present

  • Onset of signs/symptoms following ICM injection

PHYSICAL EXAM

  • Vital signs (RR, HR, BP)

  • Observation of presenting signs/symptoms including a...

TREATMENT

GENERAL MEASURES

  • Treatment considerations depend on the type of reaction (i.e., allergic-like, physiologic, CIN), presenting signs and symptoms, severity of reaction as well as the patient's ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Continue supportive care as necessary based on the patient's symptoms and clinical condition. 

REFERENCES

1
American College of Radiology Committee on Drugs and Contrast Media. ACR manual on contrast media, version 10.3. http://www.acr.org/quality-safety/resources/contrast-manual. Accessed Decem...

CODES

ICD10

  • Z91.041 Radiographic dye allergy status

  • N14.1 Nephropathy induced by oth drug/meds/biol subst

ICD9

  • 995.27 Other drug allergy

  • 580.89 Acute glomerulonephritis with other specified pathological le...

CLINICAL PEARLS

  • ICM (particularly LOCM) is a safe and effective tool for imaging patients. However, it is not without risks. These risks can be life-threatening in rare instances.

  • Proper evaluation and...

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