Skip to main content

Graft-Versus-Host Disease

Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Tissue destruction in allogeneic hematopoietic stem cell transplant (HSCT) recipients is due to donor T cells responding to host (recipient) antigens.

  • Two types: acute graft-versus-ho...

DIAGNOSIS

HISTORY

  • GVHD can affect any organ, and comprehensive history should be performed.

  • Most common sites of involvement in aGVHD include skin, GI, and hepatic organs. Skin is often the first organ ...

TREATMENT

GENERAL MEASURES

  • aGVHD is graded from I (mild) to IV (severe).

  • cGVHD is graded from 0 (mild) to 3 (severe).

MEDICATION

First Line

  • aGVHD of skin

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patients should follow up with their transplant physician, consulting physicians, and supportive care staff. 

Patient Monitoring

  • Nutritional status, including oral ...

REFERENCES

1
Martin PJ, Rizzo JD, Wingard JR, et al. First- and second-line systemic treatment of acute graft-versus-host disease: recommendations of the American Society of Blood and Marrow Transplant...

ADDITIONAL READING

Sung AD, Chao NJ. Concise review: acute graft-versus-host disease: immunobiology, prevention, and treatment. Stem Cells Transl Med.  2013;2(1):25–32. 

CODES

ICD10

  • D89.813 Graft-versus-host disease, unspecified

  • D89.810 Acute graft-versus-host disease

  • D89.811 Chronic graft-versus-host disease

  • D89.812 Acute on chronic graft-versus-host disease

ICD9

  • 279.50 Gr...

CLINICAL PEARLS

  • Acute and chronic GVHD are defined by their manifestations. aGVHD occurs early after posttransplant.

  • Skin, GIT, and liver are the common sites involved in aGVHD.

  • Rate of response and deg...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

×