Zika Virus

Jungwon Yoon, MD and Gail Scully, MD, MPH Reviewed 07/2016
 


BASICS

DESCRIPTION

  • Zika virus is a single-stranded RNA virus (family Flaviviridae).

  • Transmitted by Aedes spp. mosquitoes (especially Aedes aegypti) which also transmit dengue and chikungunya

  • Incubation e...

DIAGNOSIS

HISTORY

  • 20% of person infected with Zika virus develop symptoms.

  • Fever, myalgia, joint pain, conjunctivitis, retro-ocular pain, maculopapular rash are common symptoms (two or more usually pres...

TREATMENT

GENERAL MEASURES

  • Usually mild and self-limited infection. Treatment is supportive.

  • Aspirin or other NSAID use should be avoided if dengue infection is possible.

  • Persons with Zika virus infectio...

ONGOING CARE

  • Zika virus disease is a nationally notifiable disease, and health care providers encouraged to report suspected cases to their state health department.

  • Lab-confirmed cases should be report...

REFERENCES

Duffy MR, Chen TH, Hancock WT, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med.  2009;360(24):2536–2543.
Musso D, Nhan T, Robin E, et al. Potent...

ADDITIONAL READING

  • Meaney-Delman D, Hills SL, Williams C, et al. Zika virus infection among U.S. pregnant travelers—August 2015-February 2016. MMWR Morb Mortal Wkly Rep.  2016;65(8):211–214.

  • Oduye...

CODES

ICD10

A92.8 Other specified mosquito-borne viral fevers 

ICD9

066.3 Other mosquito-borne fever 

SNOMED

Zika virus disease (disorder) 

CLINICAL PEARLS

  • Clinical illness is generally mild and self-limited; most infections are asymptomatic.

  • Dengue virus can be cocirculating and the clinical presentation can be similar; testing to disting...

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