Acetaminophen Poisoning

Luis T. Garcia, MD Reviewed 06/2017
 


BASICS

DESCRIPTION

  • A disorder characterized by hepatic necrosis following large ingestions of acetaminophen. Symptoms may vary from initial nausea, vomiting, diaphoresis, and malaise to jaundice, confu...

TREATMENT

  • Contact a regional/local poison control center for recommendations. In the United States: (800) 222-1222

  • NAC should be given when plasma acetaminophen concentrations measured ≥4 hours after i...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • All patients should be evaluated at a health care facility.

  • Patients with evidence of organ failure, increased LFTs, or coagulopathy should be evaluated for ELT (e...

REFERENCES

Brok  J, Buckley  N, Gluud  C. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev.  2006;(2):CD003328. [View Abstract on OvidInsights]
Spiller  HA. Win...

ADDITIONAL READING

  • Major JM, Zhou EH, Wong HL, et al. Trends in rates of acetaminophen-related adverse events in the United States. Pharmacoepidemiol Drug Saf.  2016;25(5):590–598.

  • Mund ME, Quar...

SEE ALSO

Acetaminophen Poisoning, Treatment 

CODES

ICD10

  • T39.1X4A Poisoning by 4-Aminophenol derivatives, undetermined, init

  • K71.10 Toxic liver disease with hepatic necrosis, without coma

  • T39.1X1A Poisoning by 4-Aminophenol derivatives, accidental,...

CLINICAL PEARLS

  • Contact a regional poison control center for management recommendations. In the United States: (800) 222-1222

  • NAC should be given when plasma acetaminophen concentrations measured ≥4 ho...

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