Anaphylaxis

Brandon W. Bonds, MD and Adriana M. Castro, MD, DABP Reviewed 06/2017
 


BASICS

Systemic, generalized response to an allergen, usually soon after exposure 

DESCRIPTION

  • Immunologically mediated (IgE, IgG, and immune complex complement related) acute systemic reaction followin...

DIAGNOSIS

HISTORY

Rapid progression within minutes to hours of the signs and symptoms of anaphylaxis, with or without an obvious trigger, including but not limited to cutaneous symptoms such as urticar...

TREATMENT

GENERAL MEASURES

  • Treatment depends on severity.

  • Maintain a patent airway.

    • Endotracheal intubation and assisted ventilation may be necessary.

    • Possibly tracheostomy or needle cricothyrotomy in c...

ONGOING CARE

FOLLOWUP RECOMMENDATIONS

Bed rest until anaphylaxis clears and patient is hemodynamically stable 

DIET

NPO until acute symptoms are controlled 

PATIENT TEACHING

  • Asthma and Allergy Foundation o...

REFERENCES

Stone SF, Cotterell C, Isbister GK et al. Elevated serum cytokines during human anaphylaxis: identification of potential mediators of acute allergic reactions. J Allergy Clin Immunol. ...

ADDITIONAL READING

  • González-Pérez A, Aponte Z, Vidaurre CF et al. Anaphylaxis epidemiology in patients with and patients without asthma: a United Kingdom database review. J Allergy Clin Immunol.  ...

SEE ALSO

Arthropod Bites and Stings; Food Allergy 

CODES

ICD10

  • T78.00XA Anaphylactic reaction due to unspecified food, init encntr

  • T88.6XXA Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounte...

PEARLS

  • Allergy to one species of legume (e.g., peanuts) or one type of seafood (e.g., shrimp) does not mean allergy to all products in that category. Skin testing is useful.

  • Measles, mumps, rubella (MM...

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