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Anaphylaxis

Brandon W. Bonds, MD and Adriana M. Castro, MD, DABP Reviewed 06/2018
 


BASICS

Systemic, generalized response to an allergen, typically soon after exposure 

DESCRIPTION

  • Immunologically mediated (IgE, IgG, and immune complex complement related) acute systemic reaction follow...

DIAGNOSIS

HISTORY

Rapid progression (minutes to hours) of the signs and symptoms of anaphylaxis, with or without an obvious trigger, including but not limited to cutaneous symptoms such as urticaria an...

TREATMENT

GENERAL MEASURES

  • Treatment depends on severity.

  • Maintain a patent airway.

    • Endotracheal intubation and assisted ventilation may be necessary.

    • Possibly tracheostomy or needle cricothyrotomy in chi...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Bed rest until anaphylaxis clears and patient is hemodynamically stable 

DIET

NPO until acute symptoms are controlled 

PATIENT EDUCATION

  • Asthma and Allergy Foundation...

REFERENCES

1
Stone SF, Cotterell C, Isbister GK, et al; for Emergency Department Anaphylaxis Investigators. Elevated serum cytokines during human anaphylaxis: identification of potential mediators of a...

ADDITIONAL READING

  • González-Pérez A, Aponte Z, Vidaurre CF, et al. Anaphylaxis epidemiology in patients with and patients without asthma: a United Kingdom database review. J Allergy Clin Immunol. ...

SEE ALSO

Arthropod Bites and Stings; Food Allergy 

CODES

ICD10

  • T78.00XA Anaphylactic reaction due to unspecified food, init encntr

  • T88.6XXA Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounte...

CLINICAL PEARLS

  • Allergy to one species of legume (e.g., peanuts) or one type of seafood (e.g., shrimp) does not mean a patient is allergic to all products in that category. Skin testing is useful.

  • Meas...

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