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Atypical Mole (Dysplastic Nevus) Syndrome

Anne R. Atalig, MD, CPT and Terin Blanchard, MD, LTC Reviewed 06/2018
 


BASICS

Atypical mole syndrome (AMS), also known as dysplastic nevi syndrome (DNS), B-K mole syndrome, Clark nevi syndrome, or familial atypical multiple mole melanoma (FAMMM) syndrome, is a condition ...

DIAGNOSIS

AMS is a clinical diagnosis with various classifications schemes proposed. Although not widely accepted, diagnostic criteria, as defined by the NIH, require the three features of (i) maligna...

TREATMENT

MEDICATION

No medications have been shown to treat AMS (5)[C]. 

ISSUES FOR REFERRAL

  • Dermatologist for routine skin exam in patients at high risk for melanoma

  • Ophthalmologic exams for ocular nevi...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Close follow-up with a dermatologist or other experienced physician: 
  • Total body skin exam (including nails, scalp, genital area, and oral mucosa) every 6 months i...

REFERENCES

1
1 Goldsmith LA, Askin FB, Chang AE, et al. NIH consensus conference. Diagnosis and treatment of early melanoma. JAMA.  1992;268(10):1314–1319. {L-End} {L-End} [View Abstract on Ovi...

ADDITIONAL READING

  • Csoma Z, Tóth-Molnár E, Balogh K, et al. Neonatal blue light phototherapy and melanocytic nevi: a twin study. Pediatrics.  2011;128(4):e856–e864. {L-End} {L-End} [View Abstr...

CODES

ICD10

  • D22.9 Melanocytic nevi, unspecified

  • D22.4 Melanocytic nevi of scalp and neck

  • D22.30 Melanocytic nevi of unspecified part of face

  • D22.5 Melanocytic nevi of trunk

  • D22.70 Melanocytic nevi of unspe...

CLINICAL PEARLS

  • In describing nevi, “atypical” is a clinical term, whereas “dysplastic” is a histologic term.

  • Melanoma in AMS tends to arise from healthy skin despite a large number of atypical nevi.

  • ~2...

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