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Cryptogenic Organizing Pneumonia

Roselyn Jan W. Clemente-Fuentes, MD, FAAFP, Merima Bucaj, DO and Anne Marie Kennedy, DO Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Cryptogenic organizing pneumonia or COP is the idiopathic inflammatory process of diffuse interstitial granulation extending to the distal airways and alveoli.

  • As opposed to secondary...

DIAGNOSIS

Consider differential in patients presenting with 
  • Flu-like illness that lasts 4 to 10 weeks or longer. Most have been treated with empiric antibiotics without success.

  • Fatigue, fever, and wei...

TREATMENT

  • Has not been studied in randomized trials; regimens based on practice guidelines, case series, and clinical judgment

  • Observation for patients with minimal symptoms, mild radiographic involvem...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Frequent visits, weekly at first

  • Prednisone must be continued because of the chance of relapse. While on prednisone, monitor:

    • CXR and PFT every 2 ...

REFERENCES

1
Cottin V, Cordier JF. Cryptogenic organizing pneumonia. Semin Respir Crit Care Med.  2012;33(5):462–475. {L-End} [View Abstract on OvidMedline]
2
Marchiori E, Zanetti G, Hochhegger B, ...

ADDITIONAL READING

  • Cordier JF. Cryptogenic organizing pneumonia. Eur Respir J.  2006;28(2):422–446.

  • Kavakli K, Ocal N, Dogan D, et al. Is there any superiority among diagnostic methods in organizi...

CODES

ICD10

J84.116 Cryptogenic organizing pneumonia 

ICD9

516.36 Cryptogenic organizing pneumonia 

SNOMED

129458007 Bronchiolitis obliterans organizing pneumonia (disorder) 

CLINICAL PEARLS

  • COP is a restrictive problem that is completely reversible.

  • Major risk factors for COP include immunosuppression; no known association with smoking

  • Consider COP in prolonged respiratory ...

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