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Ebola Virus Disease

Sandeep Singh Jubbal, MD and Steven Hatch, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • An enveloped, negative-stranded RNA virus with a characteristic filamentous structure (family Filoviridae)

  • A high mortality rate, combined with the absence of specific antiviral treat...

DIAGNOSIS

HISTORY

  • No pathognomonic clinical signs or symptoms exist.

  • The majority of patients present with fever. Other common early symptoms include fatigue, arthralgias, myalgias, anorexia, and headac...

TREATMENT

GENERAL MEASURES

  • A few viral particles are sufficient to cause infection. Observe maximal infection control precautions.

  • The CDC recommends standard, contact, and droplet precautions for isola...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • EVD is reportable to the National Notifiable Disease Surveillance System in all U.S. states and territories.

  • Although patients may experience rapid improvement, th...

REFERENCES

1
Kennedy SB, Bolay F, Kieh M, et al. Phase 2 placebo-controlled trial of two vaccines to prevent Ebola in Liberia. N Engl J Med.  2017;377(15):1438–1447. {L-End} [View Abstract on Ovi...

ADDITIONAL READING

  • Centers for Disease Control and Prevention. Ebola virus page. http://www.cdc.gov/vhf/ebola/. Accessed February 15, 2018.

  • Uyeki TM, Mehta AK, Davey RTJr, et al. Clinical management of...

CODES

ICD10

A98.4 Ebola virus disease 

ICD9

078.89 Other specified diseases due to viruses 

SNOMED

  • 37109004 Ebola virus disease

  • 424206003 Ebolavirus

  • 422448009 Reston ebolavirus

  • 423042009 Ivory Coast ebolaviru...

CLINICAL PEARLS

  • Ebola virus is one of the most virulent human pathogens. It typically presents as an acute febrile illness with an accompanying gastrointestinal syndrome resulting in massive fluid los...

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