17-Ketosteroids, Urine (17-KS)

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Subject: 17-Ketosteroids, Urine (17-KS)

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Definition

  • 17-Ketosteroids, urine (17-KS), are breakdown products of androgens and are an adrenal function test. Examples of 17-KS include androstenedione, androsterone, estrone, and dehydroepiandrosterone. An alternative and more specific test for adrenal androgen function is dehydroepiandrosterone sulfate in serum.

  • Normal range: depends on sex and age (Table 16.2).

 
TABLE 16–2
Normal Ranges for 17-Ketosteroids in the Urine

Use

  • Evaluation of glucocorticoid production and neuroendocrine function

  • Evaluation of androgenic adrenal and testicular function in normal male individuals and primarily adrenal androgenic secretion in normal female individuals

Interpretation

Increased In

  • Adrenal tumor

  • Congenital adrenal hyperplasia (very rare)

  • Cushing syndrome

  • Ovarian cancer

  • Testicular cancer

  • Ovarian dysfunction (polycystic ovarian disease)

Decreased In

  • Addison disease

  • Castration

  • Hypopituitarism

  • Myxedema

  • Nephrosis

Limitations

 
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