Anticoagulation DNA Panel

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Subject: Anticoagulation DNA Panel

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Definition

  • The anticoagulation DNA panel tests for genetic variants in the CYP2C9 and VKORC1 genes that account for >50% of variation in warfarin response. Genotyping may reduce the need for INR surveillance as genotype-based dosing regimens are established.

  • Variants tested by the anticoagulation panel include

    • CYP2C9 *1 (normal)

    • CYP2C9 *2 (c.430C>T; Arg144Cys)

    • CYP2C9 *3 (c.1075A>C; Ile359Leu)

    • VKORC1 *1 (normal)

    • VKORC1 *2 promoter variant (c.–1639G>A)

  • Normal values:

    • CYP2C9 *1/*1

    • VKORC1 *1/*1

Use

Limitations

  • The results of a genetic test may be affected by DNA rearrangements, blood transfusion, bone marrow transplantation, or rare sequence variations.

 
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