β-Trace Protein

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Subject: β-Trace Protein

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Definition

  • β-Trace protein is also known as BTP or lipocalin-type prostaglandin D synthase. This test is currently not widely available in commercial laboratories. Research use only test. BTP, a low molecular weight glycoprotein freely filtered through the glomerular basement membrane and with minimal nonrenal elimination, is an ideal marker for GFR. BTP has been shown to be a more sensitive marker of GFR than creatinine in patients with chronic kidney disease, in kidney transplant recipients, and in children.

  • Normal range: 0.40–0.74 mg/L.

Use

  • Alternative marker for GFR in children as well as in DM and various renal diseases.

  • The early diagnosis of fistulas leaking CSF is an accurate marker of CSF leakage (CSF rhinorrhea).

Limitations

  • Patients with renal insufficiency and bacterial meningitis have increase serum and decreased CSF levels.

  • There are no clear cut and accurate cutoff values available, which is a major determinant of diagnostic significance.

Suggested Reading

Pöge  U, Gerhardt  TM, Stoffel-Wagner  B β-Trace protein is an alternative marker for GFR in renal transplantation patients. Clin Chem.  2005;51:1531.
 
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