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Subject: β-Trace Protein
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β-Trace protein is also known as BTP or lipocalin-type prostaglandin D synthase. This test is currently not widely available in commercial laboratories. Research use only test. BTP, a low molecular weight glycoprotein freely filtered through the glomerular basement membrane and with minimal nonrenal elimination, is an ideal marker for GFR. BTP has been shown to be a more sensitive marker of GFR than creatinine in patients with chronic kidney disease, in kidney transplant recipients, and in children.
Normal range: 0.40–0.74 mg/L.
Alternative marker for GFR in children as well as in DM and various renal diseases.
The early diagnosis of fistulas leaking CSF is an accurate marker of CSF leakage (CSF rhinorrhea).
Patients with renal insufficiency and bacterial meningitis have increase serum and decreased CSF levels.
There are no clear cut and accurate cutoff values available, which is a major determinant of diagnostic significance.