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Subject: Estrogen/Progesterone Receptor Assay
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Estrogen and progesterone receptors play a role in hormone-directed transcriptional activation.
Other names: estrogen receptor assay (ERA), progesterone receptor assay (PGRA), progesterone receptor protein (PRP), estrogen receptor protein (ERP).
Normal range (ERP, PRP):
Negative: <5% of nuclei staining
Borderline: 5–19% of nuclei staining
Positive: 20% of nuclei staining
To identify patients with breast cancers likely to respond to either additive or ablative hormone therapies
Assay is performed on paraffin-embedded, formalin-fixed tissue.
Receptor status is influenced by age.
The definition of positive and negative may vary from laboratory to laboratory due to tissue and antibody treatment and antibody specificity.