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Subject: Estrone

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  • Estrone (E1) is more potent than estriol (E3) but is less potent than estradiol (E2). Estrone is converted to estrone sulfate, and it acts as a reservoir that can be converted as needed to the more active estradiol. Estrone is the major circulating estrogen in postmenopausal women. In premenopausal women, estrone levels generally parallel those of estradiol, rising gradually during the follicular phase and peaking just prior to ovulation, with a secondary and smaller increase during the luteal phase. After menopause, estrone levels do not decline as dramatically as estradiol levels, possibly due to increased conversion of androstenedione to estrone.

  • Normal range:

TABLE 16–32
Reference Intervals for Estrone in Children
TABLE 16–33
Reference Intervals for Estrone in Adults*


  • Diagnosis of precocious and delayed puberty

  • Workup of suspected disorders of sex steroid metabolism

  • In the fracture risk assessment of postmenopausal women


Increased In

  • Possibly in polycystic ovarian syndrome, androgen-producing tumors, or estrogen-producing tumors.

  • Possibly increased in postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.

Decreased In

  • Inherited disorders of sex steroid metabolism

  • Testicular feminization


  • Significant diurnal variations in plasma levels

  • Digoxin and estrogens increase in plasma levels