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Estrone (E1) is more potent than estriol (E3) but is less potent than estradiol (E2). Estrone is converted to estrone sulfate, and it acts as a reservoir that can be converted as needed to the more active estradiol. Estrone is the major circulating estrogen in postmenopausal women. In premenopausal women, estrone levels generally parallel those of estradiol, rising gradually during the follicular phase and peaking just prior to ovulation, with a secondary and smaller increase during the luteal phase. After menopause, estrone levels do not decline as dramatically as estradiol levels, possibly due to increased conversion of androstenedione to estrone.
Children: see Table 16.32.
Adults: see Table 16.33.
Diagnosis of precocious and delayed puberty
Workup of suspected disorders of sex steroid metabolism
In the fracture risk assessment of postmenopausal women
Possibly in polycystic ovarian syndrome, androgen-producing tumors, or estrogen-producing tumors.
Possibly increased in postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.
Inherited disorders of sex steroid metabolism
Significant diurnal variations in plasma levels
Digoxin and estrogens increase in plasma levels