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Subject: Fibrinogen (Factor I)
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Fibrinogen is a glycoprotein synthesized in the liver. It is modified by thrombin to become fibrin, a visible clot. It is also an acute-phase reactant.
Normal range: 150–400 mg/dL (most abundant circulating clotting factor).
This test detects decreased or abnormal fibrinogen.
It may be used to determine the severity and evolution of DIC by performing serial determinations.
Because of the initial elevation of fibrinogen, its determination is not useful in the diagnosis of DIC.
Severe fibrinogen deficiency may prolong PT, PTT, and TT.
Acute inflammatory/infectious processes
Pregnancy and use of oral contraceptives
Congenital afibrinogenemia or hypofibrinogenemia.
Dysfibrinogenemia (congenital or acquired).
DIC and pathologic fibrinolysis. Fibrinogen is consumed after initial elevation as an acute-phase reactant.
Very advanced liver disease.
Clotted specimens or those obtained with the wrong anticoagulant
Inappropriately filled test tubes
Inappropriately stored blood
Hyperlipidemic, icteric, or hemolyzed blood