Glucagon

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Subject: Glucagon

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Definition

  • Polypeptide hormone secreted by the islet alpha cells in the pancreas. Stimulates the production of glucose in the liver and the oxidation of fatty acids

  • Normal range (by age):

    • Newborn (1–3 days): 0–1,750 pg/mL

    • Child (4–14 years): 0–148 pg/mL

    • Adult: 20–100 pg/mL

Interpretation

Increased In

  • Glucagonoma

  • Diabetes mellitus

  • Chronic renal failure

  • Hyperlipoproteinemia types III and IV

  • Severe stress, infections, trauma, burns, surgery, and acute hypoglycemia

Decreased In

  • Cystic fibrosis

  • Chronic pancreatitis

 
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