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Subject: High Molecular Weight Kininogen and Prekallikrein (Fletcher Factor)
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These clotting proteins activate the early phase of the intrinsic pathway and the complement system. When decreased, they may prolong PTT but not PT. They do not depend on vitamin K carboxylation.
High molecular weight kininogen: 59–135%
Extremely rare congenital deficiencies
No bleeding diathesis associated with deficiencies; reflected in prolonged PTT