High Molecular Weight Kininogen and Prekallikrein (Fletcher Factor)

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Subject: High Molecular Weight Kininogen and Prekallikrein (Fletcher Factor)

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Definition

  • These clotting proteins activate the early phase of the intrinsic pathway and the complement system. When decreased, they may prolong PTT but not PT. They do not depend on vitamin K carboxylation.

  • Normal ranges:

    • High molecular weight kininogen: 59–135%

    • Prekallikrein: 55–207%

Interpretation

Decreased In

  • Extremely rare congenital deficiencies

  • No bleeding diathesis associated with deficiencies; reflected in prolonged PTT

 
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