Immunoglobulin D (IgD)

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Subject: Immunoglobulin D (IgD)

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Definition

  • IgD is mainly found on the surface of B cells and may help regulate B-cell function. IgD likely serves as an early B-cell antigen receptor; however, the function of the circulating IgD is largely unknown. IgD functions to activate some lymphocytes.

  • Normal value: ≤15.3 mg/dL.

Use

  • Diagnosis of rare IgD myelomas (greatly increased)

Interpretation

Increased In

  • Monoclonal

    • IgD multiple myeloma

    • MGUS

  • Polyclonal

    • Chronic infection (moderately)

    • Autoimmune disease

    • Acute viral hepatitis

    • COPD

    • After allogeneic bone marrow transplantation

Decreased In

  • Hereditary deficiencies

  • Acquired immunodeficiency

  • Non-IgD myeloma

  • Infancy, early childhood

Limitations

  • An elevated IgD need to be identified as monoclonal or polyclonal by immunofixation method.

 
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