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Subject: Immunoglobulin E (IgE)
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IgE mediates allergic and hypersensitivity reactions. There is a significant overlap in total IgE between allergic and nonallergic individuals. Measurement of total IgE is not very useful as a standalone screen for allergy disease.
Normal values: see Table 16.42.
For allergy testing; IgE antibodies and skin tests are essentially interchangeable.
Indicates various parasitic diseases.
Diagnosis of E-myeloma.
Diagnosis of bronchopulmonary aspergillosis; a normal serum IgE level excludes the diagnosis.
Exogenous asthma in approximately 60% of patients
Hay fever in approximately 30% of patients
Influenced by type of allergen, duration of stimulation, presence of symptoms, and hyposensitization treatment
Parasitic diseases (e.g., ascariasis, visceral larva migrans, hookworm disease, schistosomiasis, Echinococcus infestation)
Monoclonal IgE myeloma
A normal level of IgE in serum does not eliminate the possibility of allergic disease.