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Subject: Immunoglobulin G (IgG)
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IgG activates complement and fights infection. IgG represents 70–80% of the total serum immunoglobulins in the normal adults. It exists in four subclasses (IgG1, IgG2, IgG3, and IgG4). IgG1 predominates as 65% of the total IgG. IgG of maternal origin provides passive immunity to the neonate. It is transported across the placenta.
Normal ranges: see Table 16.43.
Diagnosis of IgG myeloma
Diagnosis of hereditary and acquired IgG immunodeficiencies
Serologic diagnosis of infectious diseases and immunity
Chronic liver disease (e.g., cirrhosis)
Intrauterine contraceptive diseases
Primary immunodeficiency states
Combined with other immunoglobulin decreases:
Secondary (e.g., multiple myeloma, leukemia, nephrotic syndrome, protein-losing enteropathy)
Hereditary thymic aplasia
Type I dysgammaglobulinemia (decreased IgG and IgA and increased IgM)
Type II dysgammaglobulinemia (absent IgA and IgM and normal levels of IgG)
Infancy, early childhood