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Subject: Immunoglobulin M (IgM)
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IgM is the first antibody to appear in response to antigen. It can be produced by the fetus and cannot be crossed by the placenta.
Normal range: see Table 16.44.
Diagnosis of hereditary and acquired IgM immunodeficiencies
Diagnosis of Waldenström macroglobulinemia
Earliest Ig serologic diagnosis of infectious disease
Secondary to nephritic syndrome
Hyper IgM syndrome
Multiple myeloma (rare)
Cold IgM antibody agglutinin
Infancy, early childhood
Selective deficiency of IgM is a rare immune disorder in association with infection and normal levels of other immunoglobulin isotypes.