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Subject: Insulin-Like Growth Factor-I (IGF-I)
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IGF-I is secreted by hypothalamus; release is mediated by growth hormone (GH) in many tissues, especially hepatocytes. It is a single polypeptide chain with 70-amino-acid residues with a molecular mass of 7,649 Da. It is structurally homologous to IGF-II and insulin. IGF-I circulates primarily in a high molecular weight tertiary complex with IGF-binding protein-3 (IGFBP-3) and acid-labile subunit. Plasma IGF-I levels are barely detectable at birth, rise gradually during childhood, peak during mid-puberty until approximately 40 years of age, and then decline gradually. Maternal plasma levels increase during pregnancy.
Normal range: see Table 16.50; 0–7 days: <26 ng/mL; 8–15 days: <41 ng/mL.
Diagnosis of acromegaly and pituitary deficiency; preferable to GH because it is constant after eating and during the day
Help determine optimum dosage of GH
Screening other growth disorders
Assessing nutritional status
Monitoring effectiveness of nutritional repletion; a more sensitive indicator than prealbumin, transferrin index, or retinol-binding protein
Acromegaly and gigantism
Pregnancy (2–3 times nonpregnant values)
Anorexia or malnutrition