Mean Platelet Volume (MPV)

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Subject: Mean Platelet Volume (MPV)

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Definition

  • MPV reflects the frequency distribution of platelet volumes.

  • Normal range: 7.8–11.0 fL.

Use

  • MPV is used to evaluate variations in platelet size as related to various platelet abnormalities.

Interpretation

Increased In

  • Hypothyroidism

  • Myeloproliferative neoplasms

  • All cases of accelerated bone marrow production of platelets (immune thrombocytopenias, postchemotherapy)

  • Bernard-Soulier syndrome

Decreased In

  • Disorders associated with decreased platelet production

  • In some patients with sepsis

  • In some patients with inherited thrombocytopenias, such as Wiskott-Aldrich syndrome

Limitations

  • Reference values appear to vary with the platelet count. MPV is affected by numerous variables related to specimen collection, the anticoagulant used, temperature, and duration of storage.

 
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