Neutrophil Tests for Dysfunction


Send Email

Recipient(s) will receive an email with a link to 'Neutrophil Tests for Dysfunction' and will have access to the topic for 7 days.

Subject: Neutrophil Tests for Dysfunction

(Optional message may have a maximum of 1000 characters.)



  • Inherited or acquired disorders affecting neutrophils (and other leukocytes) may result in abnormal function and a predisposition to recurrent bacterial infections. Acquired neutrophil dysfunction may be the result of disorders of immunoglobulins, complement, or T cells; in such cases, the underlying disease should be characterized before specific assays for neutrophil dysfunction are undertaken.


  • Neutrophil function tests are used to evaluate neutrophil dysfunction in patients with recurrent bacterial infections, especially in patients with a family history suggestive of a neutrophil dysfunction syndrome. The functions used to investigate neutrophil dysfunction are adherence, locomotion, phagocytosis, and secretion (see Table 16.58). Morphologic studies are performed in parallel with the functional assays.

  • Because of the rarity of these conditions, only a limited number are mentioned (see Table 16.58).

TABLE 16–58
Assays for Suspected Congenital Neutrophil Dysfunction Syndromes