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Subject: Neutrophil Tests for Dysfunction
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Inherited or acquired disorders affecting neutrophils (and other leukocytes) may result in abnormal function and a predisposition to recurrent bacterial infections. Acquired neutrophil dysfunction may be the result of disorders of immunoglobulins, complement, or T cells; in such cases, the underlying disease should be characterized before specific assays for neutrophil dysfunction are undertaken.
Neutrophil function tests are used to evaluate neutrophil dysfunction in patients with recurrent bacterial infections, especially in patients with a family history suggestive of a neutrophil dysfunction syndrome. The functions used to investigate neutrophil dysfunction are adherence, locomotion, phagocytosis, and secretion (see Table 16.58). Morphologic studies are performed in parallel with the functional assays.
Because of the rarity of these conditions, only a limited number are mentioned (see Table 16.58).