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Subject: Protein (Total), Serum
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Total serum protein is the sum of the concentration of the circulating proteins. A total serum protein test is a blood test that measures the amounts of total protein, albumin, and globulin in the blood. The amounts of albumin and globulin also are compared (albumin/globulin ratio). Normally, there is a little more albumin than globulin, and the ratio is >1. A ratio <1 or much >1 can give clues about problems in the body.
0–7 days: 4.6–7.0 g/dL
7 days–1 year: 4.4–7.5 g/dL
1–3 years: 5.5–7.5 g/dL
3 years to adult: 6.0–8.0 g/dL
Diagnosis and treatment of diseases involving the liver, kidney, or bone marrow, as well as other metabolic or nutritional disorders
Screening for nutritional deficiencies and gammopathies
Hypergammaglobulinemias (monoclonal or polyclonal; see following sections)
Nutritional deficiency (e.g., malabsorption, Kwashiorkor, marasmus)
Decreased or ineffective protein synthesis (e.g., severe liver disease, agammaglobulinemia)
Renal (e.g., nephrotic syndrome)
GI disease (e.g., protein-losing enteropathies, surgical resection)
Severe skin disease (e.g., burns, pemphigus vulgaris, eczema)
Blood loss, plasmapheresis
Increased catabolism (e.g., fever, inflammation, hyperthyroidism, malignancy, chronic diseases)
Dilutional (e.g., IV fluids, SIADH, water intoxication)
Third trimester of pregnancy
Falsely elevated proteins (pseudohyperproteinemia) can be caused by hemoconcentration due to dehydration or sample desiccation.
Upright posture for several hours after rising increases total proteins and several other analytes