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Subject: Theophylline (1,3-Dimethylxanthine)
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A naturally occurring (tea) xanthine derivative with diuretic, cardiac stimulant, and smooth muscle relaxant properties. Other names: Theo-Dur, Uniphyl, Slo-bid, and Theolair.
0–5 months: 6–12 μg/mL
Greater than 6 months: 10–20 μg/mL
As a bronchodilator to prevent and treat asthma
Potentially toxic: 20–25 μg/mL
Serum: Quantitative immunoassay limitations
FPIA, chemiluminescence, EMIT, particle-enhanced turbidimetric inhibition immunoassay.
Do not use serum separator tubes or gels. Separate serum from cells as soon as possible.
The incidence of patients having antibodies to Escherichia coli β-galactosidase is extremely low. However, some samples containing such antibodies may result in artificially high results that do not fit the clinical profile.
Due to cross-reactivity with 1,3-dimethyluric acid (metabolite), the assay should not be used to quantitate samples from uremic patients.
If mouse antibodies are utilized, the possibility exists for interference by human antimouse antibodies (HAMA) in the sample, which could cause falsely elevated results.