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Subject: Thyroid Hormone–Binding Ratio (THBR)
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THBR values can be calculated according to the following equation proposed by the Committee on Nomenclature of the American Thyroid Association.
See Table 16.77.
Normal range: 5.93–13.13 μg/dL.
This calculated product permits correction of misleading results of T3 and T4 determinations caused by conditions that alter the thyroxine-binding protein concentration (e.g., pregnancy, estrogens, birth control pills).
States with decreased TBG (e.g., androgen treatment, chronic liver disease), protein loss, or genetically low TBG
States with increased TBG (e.g., estrogen treatment, pregnancy, acute hepatitis, genetically high TBG)
Concordance values of T4 and THBR tests suggest altered thyroid function.
Discordant variance suggests primary change in TBG in a euthyroid state (e.g., pregnancy)