Vasoactive Intestinal Polypeptide (VIP)

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Subject: Vasoactive Intestinal Polypeptide (VIP)

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Definition

  • A member of the secretin–glucagon family; highest levels in the gut and nervous system. A neuropeptide that functions as a neuromodulator and neurotransmitter. A potent vasodilator that regulates smooth muscle activity, epithelial cell secretion, and blood flow in the gastrointestinal tract. Functions as a neurohormone and paracrine mediator, being released from nerve terminals and acting locally on receptor-bearing cells

  • Normal range: 0–60 pg/mL

Use

  • Detection of VIP-secreting tumors

  • To detect occult metastases

  • To evaluate the success of surgical or drug therapies

Interpretation

Increased In

  • VIPomas

  • Neural crest tumors in children (ganglioneuroblastoma, ganglioneuroma, and neuroblastoma)

  • Pancreatic islet cell hyperplasia

  • Liver disease

  • MEN type I, pheochromocytoma

  • MTC

  • Branchiogenic carcinoma

  • Retroperitoneal histiocytoma

  • CHF

Limitations

  • This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference.

 
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