Viscosity, Serum

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Subject: Viscosity, Serum

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Definition

  • Blood viscosity is a measure of the resistance of blood to flow due to any stress. Changes in the concentration of one or more blood protein fractions will result in a change in viscosity. Blood or serum viscosity can, therefore, be used both as a diagnostic tool for the presence of diseases known to alter the proteins and as a measure of the extent of the condition.

  • Normal range: 1.10–1.80 cP (relative to water).

Use

  • Evaluate hyperviscosity syndrome associated with monoclonal gammopathy states (myeloma, Waldenström macroglobulinemia, and other dysproteinemias), including RA, SLE, and hyperfibrinogenemia.

Interpretation

Increased In

  • Increased leukocyte count

  • Thrombocytosis

  • Hyperlipoproteinemia

  • Macroglobulinemia

  • Sjögren syndrome

  • SLE

  • Lymphoproliferative disorders

  • Hyperglobulinemia associated with cirrhosis

  • Chronic active hepatitis

  • Acute thermal burns

Decreased In

  • No clinical significance

Limitations

  • Whole blood measurement is of limited use because of differences in shear rates between instrumentation and in vivo conditions.

  • Clinical symptoms do not correlate well with test results.

 
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