Recipient(s) will receive an email with a link to 'Hepatitis B Core Antibody (HBcAb; Total and IgM)' and will have access to the topic for 7 days.
Subject: Hepatitis B Core Antibody (HBcAb; Total and IgM)
(Optional message may have a maximum of 1000 characters.)
Hepatitis B core antibodies appear shortly after the onset of symptoms of hepatitis B infection and soon after the appearance of HBsAg and persists for life. Initially, anti-HBcAb consists almost entirely of the IgM class, followed by appearance of anti-HBc IgG, for which there is no commercial diagnostic assay. The anti-HBc total antibodies test, which detects both IgM and IgG antibodies and is the test for anti-HBc IgM antibodies, may be the only markers of a recent hepatitis B infection detectable in the “window period.” The window period begins with the clearance of HBsAg and ends with the appearance of antibodies to HBsAg.
Normal range: Negative.
Differential diagnosis of hepatitis; diagnosis of recent or past resolved hepatitis B infection.
HBcAb total assay: Acute, chronic, or past resolved hepatitis B infection
HBcAb IgM assay: Recent infection with hepatitis B virus (≤6 months)
Not produced after hepatitis B immunization.
Positive anti-HBc total antibody test results should be correlated with the presence of other HBV serologic markers, elevated liver enzymes, clinical signs and symptoms, and a history of risk factors.
Low levels of IgM core antibodies can sometimes be present in chronic hepatitis B, particularly during flares of activity and at times of conversion from positive antigen to positive antibody.
Neonates (<1-month-old) with positive anti-HBc total antibody results from this assay method should be tested for anti-HBc IgM antibody to rule out possible maternal anti-HBc total antibody causing false-positive results. Repeat testing for anti-HBc total antibody within 1 month is also recommended in these neonates.