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Diphtheria, pertussis, tetanus, poliomyelitis, and Haemophilus b disease prevention: Active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and invasive disease caused by H. influenzae type b in infants ≥6 weeks and children <5 years of age
Advisory Committee on Immunization Practices (ACIP) recommends that Pentacel (DTaP-IPV/Hib) may be used to provide the recommended DTaP, IPV, and Hib immunization in infants and children ≤4 years of age. Whenever feasible, the same manufacturer should be used to provide the pertussis component; however, vaccination should not be deferred if a specific brand is not known or is not available. The Hib component in Pentacel contains a tetanus toxoid conjugate. A Hib vaccine containing the PRP-OMP conjugate (PedvaxHIB) may provide a more rapid seroconversion following the first dose and may be preferable to use in certain populations (eg, American Indian or Alaska Native children) (CDC 57 2008).
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